Due to the emerging demands of huge amounts of biomedical data, new and improved data management capabilities are required for supporting a wide range of applications. Current Biomedical Databases are independently administered in geographically distinct locations, lending them almost ideally to adoption of intelligent data management approaches. As a result next generation of information infrastructure and data integration capabilities are needed to ensure increasing infrastructure agility required for high-throughput biomedical research. The symposium will focus on research issues, problems and opportunities in Biomedical Data Infrastructure. Presentations will cover a broad range of issues in (but not limited to) the following areas: